Last edited by Faemi
Tuesday, July 28, 2020 | History

10 edition of Neural Stem Cells for Brain and Spinal Cord Repair (Contemporary Neuroscience) found in the catalog.

Neural Stem Cells for Brain and Spinal Cord Repair (Contemporary Neuroscience)

by Tanja Zigova

  • 25 Want to read
  • 16 Currently reading

Published by Humana Press .
Written in English

    Subjects:
  • Cellular biology,
  • Neurosciences,
  • Neurology - General,
  • Diseases,
  • Transplantation,
  • Cerebral Palsy,
  • Cytology,
  • Medical / Nursing,
  • Neural stem cells,
  • Medical,
  • Life Sciences - Cytology,
  • Neuroscience,
  • Medical / Neuroscience,
  • Treatment,
  • Cellular therapy,
  • Central nervous system

  • The Physical Object
    FormatHardcover
    Number of Pages456
    ID Numbers
    Open LibraryOL9439088M
    ISBN 101588290034
    ISBN 109781588290038

    Spinal cord injury typically results in permanent disability. Many studies have indicated that transplantation of several different types of stem cells promotes functional recovery in animal models of spinal cord injury. A conceptually different approach to utilize stem cells for regenerative therapies may be recruitment of endogenous neural stem cells resident in the adult spinal cord. An illustration of an open book. Books. An illustration of two cells of a film strip. Video An illustration of an audio speaker. Neural stem cells for brain and spinal cord repair Item Preview remove-circle Neural stem cells for brain and spinal cord repair by Zigova, Tanja; Snyder, Evan Y; Sanberg, Paul R.

      Current research on spinal injuries has focused on restoring paths like the corticospinal tract through neural grafts that implant “newborn” cells called stem cells. By implanting stem cells into the spinal cord, researchers have found it helps to repair injured pathways and connections. Stem Cells Identified for Spinal-Cord Repair. A researcher at MIT’s Picower Institute for Learning and Memory has pinpointed stem cells within the spinal cord that, if persuaded to differentiate into more healing cells and fewer scarring cells following an injury, may lead to a new, non-surgical treatment for debilitating spinal-cord injuries.

    For scientists, clinicians, patients, and the biotech industry, transplantation of stem cells has become one of the major hopes for repair of what are currently incurable degenerative diseases and trauma to the brain and spinal cord. The 16 contributions contained in Neural stem cells for brain and spinal cord repair deal with these questions. Fan L, et al. Directing induced pluripotent stem cell derived neural stem cell fate with a three-dimensional biomimetic hydrogel for spinal cord injury repair ; 10(21): [96] Nagoshi N, Okano H. Applications of induced pluripotent stem cell technologies in spinal cord injury.


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Neural Stem Cells for Brain and Spinal Cord Repair (Contemporary Neuroscience) by Tanja Zigova Download PDF EPUB FB2

Comprehensive and up-to-date, Neural Stem Cells for Brain and Spinal Cord Repair provides the first systematic overview of the biological properties and functional characteristics of NSCs, as well as outlining of several possible areas of medicine and therapy where these cells may soon prove extremely : Hardcover.

Comprehensive and up-to-date, Neural Stem Cells for Brain and Spinal Cord Repair provides the first systematic overview of the biological properties and functional characteristics of NSCs, as well as outlining of several possible areas of medicine and therapy where these cells may soon prove extremely helpful.5/5(1).

In Neural Stem Cells for Brain and Spinal Cord Repair, active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. An exciting development for spinal cord injury research was published this week in the journal Nature Medicine.

Scientists from the University of San Diego School of Medicine transplanted human neural progenitor cells (NPCs) into rhesus monkeys that had spinal cord injuries.

These cells, which are capable of turning into other cells in the brain, survived. Neuroscientists and surgeons successfully grafted human neural progenitor cells into rhesus monkeys with spinal cord injuries. The grafts not. Implanted neural stem cell grafts show functionality in spinal cord injuries In mouse studies, the specialized grafts integrated with host networks and behaved much like neurons in a healthy.

Also in rodent models, ectopic deposits of grafted neural stem cells have been observed along the spinal cord central canal and on the surface of the spinal cord [44,45]. In the present study, we did not observe migration of implanted human neural progenitor cells in the central canal, ventricles or brain.

This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells.

It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease.

Neural stem/progenitor cell (NSPC) grafts can integrate into sites of spinal cord injury (SCI) and generate neuronal relays across lesions that can provide functional benefit. To determine if and how grafts become synaptically organized and connect with host systems, we performed calcium imaging of NSPC grafts in SCI sites in vivo and in adult.

A bioengineered spinal cord is fabricated via extrusion‐based multimaterial 3D bioprinting, in which clusters of induced pluripotent stem cell (iPSC)‐derived spinal neuronal progenitor cells (sNPCs) and oligodendrocyte progenitor cells (OPCs) are placed in precise positions within 3D printed biocompatible scaffolds during assembly.

We’ve chosen neural stem cells because they are the developmental building block of the brain and central nervous system, including the spinal cord. We are examining strategies where we can take the patient’s own skin cells and transform the cells into what is called an induced pluripotent stem cell (a cell capable of becoming a different.

Comprehensive and up-to-date, Neural Stem Cells for Brain and Spinal Cord Repair provides the first systematic overview of the biological properties and functional characteristics of NSCs, as well as outlining of several possible areas of medicine and therapy where these cells may soon prove extremely helpful.\/span>\"@ en\/a> ; \u00A0\u00A0.

The discovery of neural stem cells (NSCs) present in the adult brain and spinal cord provided evidence that the CNS may have the potential to repair insults by generating newborn neurons (Johansson et al., ; Gage, ). NSCs are self‐renewing, multipotent cells that can give rise to neurons, astrocytes and oligodendrocytes.

Introduction. Spinal cord injury (SCI) accompanied by the disruption of neural networks often causes permanent motor and sensory dysfunctions and its treatment is still a worldwide problem [].Neural stem cell / neural progenitor cell (NPC) transplantation is considered as one promising strategy to restore the neural circuitry after SCI.

The stem cells possess the ability to differentiate into multiple types of neural cell, depending upon their environment. As a result, there is great interest and much effort to use these cells to repair spinal cord injuries and effectively restore related functions. Implanted Neural Stem Cell Grafts and Functionality in Spinal Cord Injuries Researchers at the University of California San Diego School of Medicine report that they have successfully implanted specialized grafts of neural stem cells directly into spinal cord injuries in mice.

ENVIRONMENT OF THE INJURED CNS: CHALLENGES AND OPPORTUNITIES. The evolution of the neural injury response involves a dynamic interplay between events promoting repair and regeneration and those of damage and inhibition (see Figure for an overview).

Physical insults to brain or spinal cord tissue initially cause necrotic cell death and damage in the underlying tissue.

In a new study published in Cell Stem Cell, researchers at University of California San Diego School of Medicine report successfully implanting highly specialized grafts of neural stem cells directly into spinal cord injuries in mice, then documenting how the grafts grew and filled the injury sites, integrating with and mimicking the animals' existing neuronal network.

The fact that different types of stem cells present different ethical, practical and immunological issues has certainly been obscured.

The scientific arguments are laid out in Zigova, Snyder and Sanberg's multi-author work Neural stem cells for brain and spinal cord repair. The least challenging source of stem cells, from an ethical view, is. Results from SCI models showed that transplantation of stem cells or progenitors may support spinal cord repair through the replacement of lost neural cells and the attenuation of gliosis around.

Paul R. Sanberg has 11 books on Goodreads with 10 ratings. Paul R. Sanberg’s most popular book is Neural Stem Cells for Brain and Spinal Cord Repair (Con. Apr. 24, — Scientists have created a special type of neuron from human stem cells that could potentially repair spinal cord injuries. These cells, called V2a interneurons, transmit signals.Instead of trying to use healthy adult human neural pathway as the only blueprint to repair the spinal cord or brain, the reported data suggested that researchers and physicians should also look into how to identify unconventional neural circuits that can be harnessed for recovering function of the targeted motor or sensory system.