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Tuesday, August 4, 2020 | History

1 edition of Reactivity Tuning in Oligosaccharide Assembly found in the catalog.

Reactivity Tuning in Oligosaccharide Assembly

Bert Fraser-Reid

Reactivity Tuning in Oligosaccharide Assembly

by Bert Fraser-Reid

  • 228 Want to read
  • 3 Currently reading

Published by Springer-Verlag Berlin Heidelberg in Berlin, Heidelberg .
Written in English

    Subjects:
  • Biochemistry,
  • Polymers,
  • Carbohydrates,
  • Chemistry

  • Edition Notes

    Statementedited by Bert Fraser-Reid, J. Cristóbal López
    SeriesTopics in Current Chemistry -- 301
    ContributionsCristóbal López, J., SpringerLink (Online service)
    The Physical Object
    Format[electronic resource] /
    ID Numbers
    Open LibraryOL25538786M
    ISBN 109783642209130, 9783642209147

      The programmable one-pot oligosaccharide synthesis method was designed to enable the rapid synthesis of a large number of oligosaccharides, using . The assembly of an oligosaccharide library has been achieved in a practical and efficient manner employing a one-pot sequential approach. With the help of the anomeric reactivity values of thioglycosides, using a thioglycoside (mono- or disaccharide) with one free hydroxyl group as acceptor and donor coupled with another fully protected thioglycoside, a di- or trisaccharide is selectively.

    This was achieved by carefully tuning the reactivity of the glycosyl donors by employing our cyclohexane‐1,2‐diacetal (CDA) methodology. The method was further extended with one‐pot procedures for oligosaccharide synthesis, thus reducing the number of steps to form the protected nonasaccharide 21 from the monosaccharide building blocks to. CPS plays a major role in S. pneumoniae virulence.A commercial valent polysaccharide vaccine was introduced in , followed by a valent vaccine in Serotype 3 of S. pneumoniae is one of the most prevalent serotypes causing acute otitis media and is one of the thirteen serotypes included in the blockbuster pneumococcal conjugate vaccine Prevnar 13 ®.

    Codée J D C, Christina A E, Walvoort M T C, Overkleeft H S, van der Marel G A. Uronic Acids in Oligosaccharide and Glycoconjugate Synthesis. In: Fraser-Reid B, Lopez J C, editors. Reactivity Tuning in Oligosaccharide Assembly. Vol. Berlin: Springer-Verlag; pp. – Oligosaccharide synthesis remains a challenging area of research, where we are yet to see methodology of sufficient generality to be applicable to most, and certainly not all, targets. Nonetheless, the toolbox of conditions, glycosyl donors and strategies is increasing, and so is our understanding of the forces that govern reactivity and.


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Reactivity Tuning in Oligosaccharide Assembly by Bert Fraser-Reid Download PDF EPUB FB2

Reactivity Tuning in Oligosaccharide Assembly (Topics in Current Chemistry Book ) - Kindle edition by Fraser-Reid, Bert, Cristóbal López, J. Download it once and read it on your Kindle device, PC, phones or tablets.

Use features like bookmarks, note taking and highlighting while reading Reactivity Tuning in Oligosaccharide Assembly (Topics in Current Chemistry Book ).Manufacturer: Springer. Reactivity Tuning in Oligosaccharide Assembly (Topics in Current Chemistry ()) [Fraser-Reid, Bert, Cristóbal López, J.] on *FREE* shipping on qualifying offers.

Reactivity Tuning in Oligosaccharide Assembly (Topics in Current Chemistry ()). Armed–Disarmed Effects in Carbohydrate Chemistry: History, Synthetic and Mechanistic Studies, by Bert Fraser-Reid and J. Cristóbal López A Survey of Ley’s Reactivity Tuning in Oligosaccharide Synthesis, by Ana M.

Gómez “Active–Latent” Thioglycosyl Donors and Acceptors in Oligosaccharide Syntheses, by Tze Chieh Shiao and René Roy Effect of Electron-Withdrawing Protecting Groups at.

ISBN: OCLC Number: Description: xv, pages: illustrations. Contents: Armed-disarmed effects in carbohydrate chemistry: history, synthetic and mechanistic studies / B. Fraser-Reid and J.C. López --A Survey of Ley's Reactivity Tuning in Oligosaccharide Synthesis / A.M.

Gómez --"Active-latent" thioglycosyl donors and. ISBN: OCLC Number: Description: XV, Seiten: Illustrationen, Diagramme. Contents: Armed-Disarmed Effects in Carbohydrate Chemistry: History, Synthetic and Mechanistic Studies, by Bert Fraser-Reid and J.

Cristobal Lopez: Armed-Disarmed Effects in Carbohydrate Chemistry * A Survey of Ley's Reactivity Tuning in Oligosaccharide. Reactivity Tuning in Oligosaccharide Assembly. por. Topics in Current Chemistry (Book ) ¡Gracias por compartir. Has enviado la siguiente calificación y reseña.

Lo publicaremos en nuestro sitio después de haberla : Springer Berlin Heidelberg. Reactivity Tuning in Oligosaccharide Assembly. Editors: Fraser-Reid, Bert, Cristóbal López, J. (Eds.) Free Preview.

This series presents critical reviews of the present position and future trends in modern chemical research. Short and concise reports on chemistry, each written by the world renowned experts “In this book, the various.

Reactivity Tuning in Oligosaccharide Assembly Bert Fraser-Reid, J. Cristóbal López (auth.), Bert Fraser-Reid, J. Cristóbal López (eds.) See Table of Contents (PMP). Book. Reactivity Tuning in Oligosaccharide Assembly.

Volume ISBN: This chapter summarizes the concepts and chemistry developed by Ley’s group in relation to the relevance of reactivity tuning in oligosaccharide coupling reactions. The recognition that protecting groups affect the reactivity of glycosyl donors allowed Ley’s group to make imaginative use of their 1,2-diacetal protecting groups.

Reactivity Tuning in Oligosaccharide Assembly Volume Editors: Bert Fraser-Reid, J. Cristo´bal Lo´pez Vol.Luminescence Applied in Sensor Science Volume Editors: Luca Prodi, Marco Montalti, Nelsi Zaccheroni Vol.Chemistry of Opioids Volume Editor: Hiroshi Nagase Vol.Electronic and Magnetic Properties of Chiral.

Download Reactivity Tuning in Oligosaccharide Assembly (Topics in Current Chemistry Book ) (English Edition) rtf Download Book Add Comment Reactivity Tuning in Oligosaccharide Assembly (Topics in Current Chemistry Book ) (English Edition) Edit. Reactivity Tuning in Oligosaccharide Assembly.

Topics in Current Chemistry (Book ) Thanks for Sharing. You submitted the following rating and review. Brand: Springer Berlin Heidelberg. The concise preparation of complex oligosaccharides remains a significant challenge for synthetic organic chemistry.

The tuning of donor reactivity during coupling reactions, such that we may avoid the lengthy protecting-group manipulations of classical carbohydrate synthesis, affords a strategy for the rapid assembly of large sugar systems.

Book Review of Reactivity Tuning in Oligosaccharide Assembly Reactivity Tuning in Oligosaccharide Assembly. Edited by Bert Fraser-Reid (Pittsboro, NC) and José Cristóbal López. This chapter describes the assembly of uronic acid containing oligosaccharides and glycoconjugates.

Two strategies are available to access these target molecules, namely a pre-glycosylation oxidation approach, in which uronic acid building blocks are used, and a post-glycosylation oxidation strategy, which employs an oxidation step after the assembly of the oligosaccharide chain.

Diacetal-mediated reactivity tuning was used in the assembly of complex oligosaccharides such as the high-mannose nonasaccharide from HIV gp 16 and, more recently, a glycosylphosphatidylinositol (GPI) anchor of Trypanosoma brucei.

17 Furthermore the use of ‘one-pot’ procedures allows quicker entry to many of the target molecules. Post-synthetic aglycon modification of substituted aryl thioglycosides led to building blocks with multiple levels of anomeric reactivities, which can be used in rapid assembly of oligosaccharides in.

This paper describes the application of 1,2-diacetal protecting groups to control the reactivity tuning of glycosyl fluorides in oligosaccharide coupling reactions. The synthetic potential of this new methodology is demonstrated by the ‘one-pot’ synthesis of a linear pentasaccharide and the efficient assembly of the core oligosaccharide of.

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Book Annex Membership Educators Gift Cards Stores & Events Help Auto Suggestions are available once you type at least 3 letters. Author: Bert Fraser-Reid. Find many great new & used options and get the best deals for Topics in Current Chemistry Ser.: Reactivity Tuning in Oligosaccharide Assembly (Trade Cloth) at the best online prices at eBay!

Free shipping for many products!REACTIVITY TUNING IN OLIGOSACCHARIDE ASSEMBLY, - Series: Topics in Current Chemistry, SPRINGER-VERLAG BERLIN: Book Part: Publisher: which employs an oxidation step after the assembly of the oligosaccharide chain.

Because uronic acid building blocks are generally considered to be less reactive than their non-oxidized.Reactivity Tuning in Oligosaccharide Assembly de - English books - commander la livre de la catégorie sans frais de port et bon marché - Ex Libris boutique en ligne.